Graham Diering

  • Status: Postdoctoral fellow

  • Hometown: Vancouver, B.C., Canada

  • Research Project: Regulation of AMPA receptor synapse targeting during homeostatic plasticity.

  • Publications:

    1. Hussain, N.K., Diering, G., Sole, J., Anggono, V., Huganir, R.L. (2014) Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Proc Natl Acad Sci USA. 111(32): 11840-5. PMCID: PMC4136608.

    2. Diering, G., Gustina, A., Huganir, R.L. (2014) PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron. 84(4): 790-805. PMCID: PMC4254581.

    3. Diering GH, Numata M. Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5. (2014). Frontiers in Physiology. 4: 412. Invited review.

    4. Diering GH*, Numata Y*, Fan S, Church J, Numata M. Endosomal Acidification by Na+/H+ Exchanger NHE5 Regulates TrkA Cell-Surface Targeting and NGF-Induced PI3K Signaling. (2013). Molecular Biology of the Cell. 24: 3435-48. *Equal contribution.

    5. Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M. (2012). Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. Journal of Biological Chemistry 287:17530-45.

    6. Balgi AD, Diering GH, Donohue E, Lam KK, Fonseca BD, Zimmerman C, Numata M, Roberge M. (2011). Regulation of mTORC1 Signaling by pH. PLoS One. 6:e21549.
Diering GH, Mills F, Bamji SX, Numata M. Regulation of Dendritic Spine Growth Through Activity-Dependent Recruitment of Brain-Enriched Na+/H+ Exchanger NHE5. (2011). Molecular Biology of the Cell. 22: 2246-57.

    7. Diering GH, Church J, Numata M. (2009). Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. Journal of Biological Chemistry 284: 13892-903.

    8. Onishi I, Lin PJ, Diering GH, Williams WP, Numata M. (2007). RACK1 Associates with NHE5 in Focal Adhesions and Positively Regulates the Transporter Activity. Journal of Cell Signaling 19:194-203.