Natasha K. Hussain

  • Status: Scientific Director of Kavli NDI

  • Hometown: London, Ontario, Canada

  • Education:
    • McGill University, BSc. Biology and Environmental Science
    • McGill University, Montreal Neurological Institute, PhD. Neurology and Neurosurgery
    • MIT, Picower Institute, Post-doctoral Fellow

  • Personal Interests: Accomplished equestrian, I enjoy nature, as well as big cities, traveling, creating digital-art; consumer of writing, performance, and steak; recent unserious attempts at gardening and industrial-style art fabrication. Mostly, I enjoy turning laboratory research into innovation and work to make my children laugh every day.

  • Research Project:

    • Characterization of synaptic connectivity and strength regulated by post-translational modification of AMPAR subunits in disease model systems.

  • Publications:

    1. Hussain, N.K., Huganir, R.L. (in revision) Structure and Molecular Organization of the Postsynaptic Density. In G. Stuart, N. Spruston, and M. Hausser (Eds.), Dendrites. (3rd Edition) Oxford University Press.

    2. Hussain, N.K., Diering, G., Sole, J., Anggono, V., Huganir, R.L. Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. (2014) Proceedings of the National Academy of Sciences USA. 111(32):11840-5.

    3. Selvakumar, B., Jenkins, M.A., Hussain, N.K., Huganir, R.L., Traynelis, S.F., Snyder, S.H. S-Nitrosylation of AMPA Receptor GluA1 regulates phosphorylation, single channel conductance and endocytosis. (2013) Proceedings of the National Academy of Sciences USA. 110(3):1077-82.

    4. Hussain, N.K., Hsin, H., Huganir, R.L., Sheng, M. MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. (2010) The Journal of Neuroscience 30(44):14786-14794.

    5. Bhakar, A.L., Hussain, N.K., Bear, M.F. The role of the NR2 NMDA receptor subunits in visual cortical plasticity. (2007) Cellscience Reviews 3(3): 68-84.

    6. Hussain, N.K., Sheng, M. Neuroscience. Making synapses: a balancing act. (2005) Science 307(5713): 1207-8.

    7. Blondeau, F., Ritter, B., Allaire, P.D., Wasiak, S., Girard, M., Hussain, N.K., Angers, A., Legendre-Guillemin, V., Roy, L., Boismenu, D., Kearney, R.E., Bell, A.W., Bergeron, J.J.M., McPherson, P.S. Tandem mass spectrometry analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. (2004) Proceedings of the National Academy of Sciences, 101: 3833-3838.

    8. Legendre-Guillemin, V. Wasiak, S., Hussain, N.K., Angers, A. and McPherson, P.S. ENTH/ANTH proteins and clathrin-mediated membrane budding. (2004) The Journal of Cell Science 117: 9-18.

    9. Hussain, N.K., Yamabhai, M., Bhakar, A.L., Metzler, M., Ferguson, S.S.G., Hayden, M.R., McPherson, P.S., and Kay, B.K. A role for Epsin N-terminal Homology/AP180 N-terminal Homology (ENTH/ANTH) domains in tubulin binding. (2003) The Journal of Biological Chemistry 278: 28823-30.

    10. Barker, P.A, Hussain, N.K., and McPherson, P.S. Retrograde signaling by the neurotrophins follows a well worn trk (2002) Trends in Neurosciences 25: 379-381.

    11. Jenna, S., Hussain, N.K., Danek, E., Triki, I., Wasiak, S., McPherson, P.S. and Lamarche-Vane, N. The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. (2002) The Journal of Biological Chemistry 277: 6366-73.

    12. Hussain, N.K., Jenna, S., Glogauer, M., Quinn, C.C., Wasiak, S., Guipponi, M., Antonarakis, S.E., Kay, B.K., Stossel, T.P., Lamarche-Vane, N., and McPherson, P.S. Endocytic protein intersectin-l regulates actin dynamics via Cdc42 and N-WASP. (2001) Nature Cell Biology 3: 927-932.

    13. McPherson, P.S. Kay, B.K., and Hussain, N.K. Signaling on the endocytic pathway. (2001) Traffic 2: 375-384.

    14. Tong, X-K., Hussain, N.K., Adams, A., O’Bryan, J.P., and McPherson, P.S. (2000) Intersectin Can Regulate the Ras/MAP-kinase pathway independently of its role in endocytosis. The Journal of Biological Chemistry 275: 29894-29899.

    15. Tong, X-K., Hussain, N.K., de Heuvel, E., Kurakin, A., Abi-Jaoude, E., Quinn, C.C., Olson, M.F., Marais, R., Baranes, D., Kay, B.K., and McPherson. The endocytic protein intersectin is a major binding partner for the RAS exchange factor mSOS in rat brain. (2000) EMBO Journal 19: 1263-271.

    16. Simpson, F.S., Hussain, N.K., Qualmann, B., Kay, B.K., Kelly, R.B., McPherson, P.S., and Schmid, S.L. SH3 domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. (1999) Nature Cell Biology 1: 119-124.

    17. Hussain, N.K., Yamabhai, M., Ramjaun, A.R., Guy, A.M., Baranes, D., O’Bryan, J.P., Der, C.J., Kay, B.K., and McPherson, P.S. Splice variants of intersectin are components of the endocytic machinery in neurons and non-neuronal cells. (1999) The Journal of Biological Chemistry 274: 15671-15677.