Synaptic computation and sensory representation in the mouse visual cortex
Development of kinase biosensors for multiplex neuronal imaging of signaling pathways in vivo
Publications:
Zhang JF*, Liu B*, Hong I*, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Nat Chem Biol. 2021 Jan;17(1):39-46. *co-first author
Song S, Kim J, Park K, Lee J, Park S, Lee S, Kim J, Hong I*, Song B*, Choi S*. GSK-3β activation is required for ZIP-induced disruption of learned fear. Sci Rep. 2020 Oct 26;10(1):18227. doi: 10.1038/s41598-020-75130-5. *co-corresponding author
Araki Y, Hong I, Gamache TR, Ju S, Collado-Torres L, Shin JH, Huganir RL. SynGAP isoforms differentially regulate synaptic plasticity and dendritic development. Elife. 2020 Jun 24;9
Graves A, Roth R, Tan H, Zhu Q, Bygrave A, Lopez-Ortega E, Spiegel A, Hong I, Johnson R, Vogelstein J, Tward D, Miller M, Huganir R. Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. bioRxiv. 2020 January; :2020.03.01.972216.
Roth RH, Cudmore RH, Tan HL, Hong I, Zhang Y, Huganir RL. Cortical Synaptic AMPA Receptor Plasticity during Motor Learning. Neuron. 2019 Dec 26. pii: S0896-6273(19)31047-5.
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Dec 6;96(5):1084-1098.
Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA, Kwon C. Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Rep. 2017 Jan 10;18(2):571-582.
Park S, Lee J, Park K, Kim J, Song B, Hong I, Kim J, Lee S, Choi S. Sound tuning of amygdala plasticity in auditory fear conditioning. Sci Rep. 2016 Aug 4;6:31069
Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons. Cell Stem Cell. 2016 Jul 7;19(1):95-106
Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL. The nutrient sensor OGT in PVN neurons regulates feeding. Science. 2016 Mar 18;351(6279):1293-6
Kim J, An B, Kim J, Park S, Park S, Hong I, Lee S, Park K, Choi S. mGluR2/3 in the Lateral Amygdala is Required for Fear Extinction: Cortical Input Synapses onto the Lateral Amygdala as a Target Site of the mGluR2/3 Action. Neuropsychopharmacology. 2015 Dec;40(13):2916-28
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 2015 Sep 3;525(7567):56-61
Kang T, Kim JH, Hong I, Park NH, Heinsen H, Lee JY, Ravid R, Ferrer I, Yoo JS, Kwon KH, Park YM. (2014) Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment. Anal Bioanal Chem. 406(22):5433-46.
Park K, Song B, Kim J, Hong I, Song S, Lee J, Park S, Kim J, An B, Lee HW, Lee S, Kim H, Lee JC, Lee S, Choi S. (2014) ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala. PLoS One. 12;9(6):e100108.
*Lee S, *Song B, *Kim J, Park K, Hong I, An B, Song S, Lee J, Park S, Kim J, Park D, Lee CJ, Kim K, Shin KS, Tsien RW, Choi S. (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal. Nature Neuroscience. 16(10):1436-44.
*Hong I, *Kim J, *Kim J, Lee S, Ko HG, Nader K, Kaang BK, Tsien RW, Choi S. (2013) AMPA receptor exchange underlies transient memory destabilization on retrieval. Proceedings of the National Academy of Sciences of the United States of America. 110(20):8218-23. (* equal contribution)
*Hong I, *Kang T, *Yoo Y, *Park R, Lee J, Lee S, Kim J, Song B, Kim SY, Moon M, Yun KN, Kim JY, Mook-Jung I, Park YM, Choi S. (2013) Quantitative proteomic analysis of the hippocampus in the 5XFAD mouse model at early stages of Alzheimer's disease pathology. Journal of Alzheimer's Disease. 36(2):321-34. (* equal contribution)
*Hong I, *Kang T, *Yun KN, Yoo Y, Park S, Kim J, An B, Song S, Lee S, Kim J, Song B, Kwon KH, Kim JY, Park YM, Choi S. (2013) Quantitative proteomics of auditory fear conditioning. Biochemical and Biophysical Research Communications. 434(1):87-94. (* equal contribution)
*An B, *Hong I, Choi S. (2013) Long-term neural correlates of reversible fear learning in the lateral amygdala. Journal of Neuroscience. 32(47):16845-56. (* equal contribution)
Hong I, Kim J, Song B, Park K, Shin K, Eom KD, Han PL, Lee S, Choi S. (2011) Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices. Neuroscience Letters. 506(1):121-5.
Hong I, Kim J, Lee J, Park S, Song B, Kim J, An B, Park K, Lee HW, Lee S, Kim H, Park SH, Eom KD, Lee S, Choi S. (2011) Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation. PLoS One. 6(9): e24260.
*Hong I, *Kim J, Song B, Park S, Lee J, Kim J, An B, Lee S, Choi S. (2011) Modulation of fear memory by retrieval and extinction: a clue for memory deconsolidation. Reviews in the Neurosciences. 22(2):205-29. Invited review (* equal contribution)
Kim J, Song B, Hong I, Kim J, Lee J, Park S, Eom JY, Lee CJ, Lee S, Choi S. (2010) Reactivation of fear memory renders consolidated amygdala synapses labile. Journal of Neuroscience. 30(28):9631-40.
Hong I, Song B, Lee S, Kim J, Kim J, Choi S. (2009) Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala. European Journal of Neuroscience. 30(11):2089-99.
*Kim J, *Lee S, *Park K, *Hong I, *Song B, Son G, Park H, Kim WR, Park E, Choe HK, Kim H, Lee C, Sun W, Kim K, Shin KS, Choi S. (2007) Amygdala depotentiation and fear extinction. Proceedings of the National Academy of Sciences of the United States of America. 104(52):20955-60. (* equal contribution)
Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S. Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction. (2007) Biochemical and Biophysical Research Communications. 355(1):188-93.
