Selected Publications

For a full list of publication, please click here.

Our laboratory is interested in the molecular mechanisms that modulate the communication between neurons in the brain. This modulation is critical for complex processes in the brain, including learning and memory and development. You can find out more about our work by clicking on "Research focus".

Graves AR*, Roth R*, Tan H*, Zhu Q*, Bygrave A*, Lopez-Ortega E, Spiegel A, Hong I, Johnson R, Vogelstein J, Tward D, Miller M, Huganir R (2020). Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. BioRxiv
Tan H, Roth R, Graves AR, Cudmore R, Huganir R (2020). Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. eLife
Yong AJH, Tan HL, Zhu Q, Bygrave AM, Johnson RC, Huganir RL (2020) Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. PNAS. PMID: 32071234
Gamache TR, Araki Y, Huganir RL. (2020) Twenty Years of SynGAP Research: From Synapses to Cognition.. J Neurosci. PMID: 32075947
Renuse S, Madugundu AK, Jung JH, Byeon SK, Goldschmidt HL, Tahir R, Meyers D, Kim DI, Cutler J, Kim KP, Wu X, Huganir RL, Pandey A (2020) Signature Fragment Ions of Biotinylated Peptides. J Am Soc Mass Spectrom. PMID: 31939678
Roth RH, Cudmore RH, Tan HL, Hong I, Zhang Y, Huganir RL. (2019) Cortical Synaptic AMPA Receptor Plasticity during Motor Learning. Neuron. PMID: 31901303
Mejias R, Chiu SL, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. (2019) Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiol Dis. PMID:31476380
Diering GH, Huganir RL (2018). The AMPA Receptor Code of Synaptic Plasticity. Neuron. PMID: 30359599
Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J. (2018). Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities. Nat Cell Biol. PMID: 30250062
Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ (2018). Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. PMID: 29706584.
Kim DI, Cutler JA, Na CH, Reckel S, Renuse S, Madugundu AK, Tahir R, Goldschmidt HL, Reddy KL, Huganir RL, Wu X, Zachara NE, Hantschel O, Pandey A (2018). BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation. J Proteome Res. PMID: 29249144.
Barber CN, Huganir RL, Raben DM. (2018) Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD? Adv Biol Regul. PMID: 28986032.
Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandey A, Huganir RL. (2018) Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. PNAS. 17;115(16):E3827-E3836. PMCID: PMC5910858.
Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, Niranjan T, Schwartz CE, Wang T, Huganir RL. (2017) GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 93(6):1405-1419. PMCID: PMC5382714.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. (2017) Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 355(6324):511-515. PMCID: PMC5382711.
Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. (2016) Extensive phosphorylation of AMPA receptors in neurons. PNAS. 113(33):E4920-7. PMCID: PMC4995952.
Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL. (2016) The nutrient sensor OGT in PVN neurons regulates feeding. Science. 351(6279):1293-6. PMCID: PMC4817221.
Zhang, Y., Cudmore, R., Lin, D-T., Linden, D., Huganir, R.L. (2015) Visualization of NMDA Receptor-Dependent AMPA Receptor Synaptic Plasticity In Vivo Nature Neuroscience. 18(3): 402-7. PMCID: PMC4339371.
Diering, G., Gustina, A., Huganir, R.L. (2014) PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron. 84(4): 790-805. PMCID: PMC4254581.
Sia, G.M., Clem, R. L., Huganir, R.L. (2013) The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science. 342(6161): 987-91. PMCID: PMC3903157.
Volk, L.J., Bachman, J.L., Johnson, R., Yu. Y., Huganir, R.L. (2013) PKMz is not required for hippocampal synaptic plasticity, learning and memory. Nature. 493(7432): 420-3. PMCID: PMC3830948.
Makuch, L., Volk, L., Anggono, V., Johnson, R., Yu, Y., Duning, K., Kremerskothen, J., Xia, J., Takamiya, K., Huganir, R.L. (2011) Regulation of AMPA Receptor Function by the Memory-Associated Gene KIBRA. Neuron. 71(6): 1022-9. PMCID: PMC3200575.
Clem, R., Huganir, R.L. (2010) Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science. 330(6007): 1108-12. PMCID: PMC3001394.
Lin, D.T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., Huganir, R.L. (2009) Regulation of AMPA receptor GluR1 subunit extrasynaptic insertion events by 4.1N, phosphorylation and palmitoylation. Nat. Neurosci. 12(7): 879-87. PMCID: PMC2712131.
Steinberg, J.P., Takamiya, K., Shen, Y., Xia, J., Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., Huganir, R.L. (2006) Targeting In Vivo Mutations of the AMPA Receptor Subunit GluR2 and its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression. Neuron. 49(6):845-60.
Chung, H.J., Steinberg, J.P., Huganir, R.L. and Linden, D.J. (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
Lee, H-K., Takamiya, K., Han, J-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R.S., Wenthold, R.J., Gallagher, M., and Huganir, R.L. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112:631-642.
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M.F., and Huganir, R.L. (2000) Reversible changes in distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955-959.
Dong, H., O'Brien, R.J., Fung, E.T., Lanahan, A.A., Worley, P.F. and Huganir, R.L. (1997) GRIP: a synapticPDZ domain-containing protein that interacts with AMPA receptors. Nature 386:279-284.
Ehlers, M.D., Zhang, S., Bernhardt, J.P. and Huganir, R.L. (1996) Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell, 84:745-755.
Ehlers, M.D., Tingley, W.G. and Huganir, R.L. (1995) Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science 269:1734-1737.