publications

Selected Publications

For a full list of publication, please click here

Our laboratory is interested in the molecular mechanisms that modulate the communication between neurons in the brain. This modulation is critical for complex processes in the brain, including learning and memory and development. You can find out more about our work by clicking on "Research focus".


	Mejias, R., Adamczyk, A., Anggono, V., Niranjan, T., Thomas, G.M., Sharma, K., Skinner, C., Schwartz, C.E., Stevenson, R.E., Fallin, M.D., Kaufmann, W., Pletnikov, M., Valle, D., Huganir, R.L., Wang, T. (2011) Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci USA. 108(12): 4920-5.

	Clem, R., Huganir, R.L. (2010) Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science 330(6007): 1108-12.

	Hayashi, T., Thomas, G., Huganir, R.L. (2009) Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron 64(2): 213-226.

	Lin D.T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K. and Huganir, R.L. (2009) Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nature Neuroscience 12(7): 879-87.

	Sia, G.M., Beique, J.C., Rumbaugh, G., Cho, R., Worley, P.F., Huganir, R.L. (2007) Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron. 55(1):87-102.

	Steinberg, J.P., Takamiya, K., Shen, Y., Xia, J., Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., Huganir, R.L. (2006) Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 49(6):845-60.

	Chung, H.J., Steinberg, J.P., Huganir, R.L. and Linden, D.J. (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.

	Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R.S., Wnethold, R.J., Gallagher, M., and Huganir, R.L., (2003) Phosphorylation of the AMPA recpetor GluR1 subunit is required for synpatic plasticity and rentention of spatial memory. Cell. 112:631-642.

	Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M.F., and Huganir, R.L. (2000) Regulation of distinct AMPA recpetor phosphorylation sites during bidrectional synaptic plasticity. Nature 405: 955-959.

	Ehlers, M.D., Zhang, S., Bernhardt, J.P., and Huganir, R.L. (1996) Inactivation of NMDA receptors by direct interaction of calmodulin with NR1 subunit. Cell 84:745-755.